Our Research

The Manchester Breathomics Group is focused on understanding biological mechanisms of respiratory disease, and developing breath analysis towards fast and accurate diagnosis.

 

Breathomics and Volatomics

Derived from Metabolomics, Breathomics and Volatomics are multi-disciplinary scientific fields spanning analytical and environmental chemistry, microbiology, and clinical science. Breathomics is concerned with profiling endogenous and exogenous metabolites and chemicals found in a sample of breath.


Exhaled Breath Volatile Organic Compounds

Volatile organic compounds (VOCs) are organic chemicals that have a high vapour pressure at ordinary room temperature. The exhaled human breath contains thousands of VOCs which can be produced by metabolic processes, or inhaled/absorbed from exogenous sources. Currently, researchers either profile differences between test and control samples using devices such as e-noses, or develop a chemical fingerprint by more advanced mass spectrometry or ion mobility methods.


Exhaled Breath Condensate

Exhaled breath condensate (EBC) is the exhalate from breath, that has been condensed, typically via cooling using a collection device. EBC reflects changes in the respiratory fluid that lines the airways and is an inexpensive, non-invasive tool that has potential for scientific research.

 

 

For further information, please see our publications page for reviews